12-year-old Jackie (Frouke Verheijde) is a regular at the Rijksmuseum. Her mother Mouna (Karina Smulders) works there as a curator. When the famous Rembrandt paintings by Marten Soolmans and Oopjen Coppit are exhibited, something wonderful happens. When Jackie walks past their portraits after closing time, Oopjen's (Sarah Bannier) eyes follow her. Jackie thought she was just imagining it, but that turns out not to be the case. Suddenly Oopjen is standing front of her, but Jackie doesn't want to believe it. She thinks it is a costumed actress. But it soon becomes clear that Oopjen is telling the truth. She stepped out of the painting because she thought that Jackie was Aeltje, the sister she has lost for years. When Oopjen realizes her mistake she is confused. But the tough Jackie has a big heart and she's used to solving everyone's problems. She secretly takes Oopjen home so they can look for the painting of the lost sister together. But how is Oopjen going to return to the painting?